Attacking heterogeneity in schizophrenia by deriving clinical subgroups from widely available symptom data
Previous research has identified (1) a “deficit” subtype of schizophrenia characterized by
enduring negative symptoms and diminished emotionality and (2) a “distress” subtype
associated with high emotionality—including anxiety, depression, and stress sensitivity.
Individuals in deficit and distress categories differ sharply in development, clinical course
and behavior, and show distinct biological markers, perhaps signaling different etiologies.
We tested whether deficit and distress subtypes would emerge from a simple but novel data …
enduring negative symptoms and diminished emotionality and (2) a “distress” subtype
associated with high emotionality—including anxiety, depression, and stress sensitivity.
Individuals in deficit and distress categories differ sharply in development, clinical course
and behavior, and show distinct biological markers, perhaps signaling different etiologies.
We tested whether deficit and distress subtypes would emerge from a simple but novel data …
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